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Particularly India, although a lower adult obesity prevalence, has a large absolute number of patients and prices have already fallen by up to 90% (see pricing section below) in what looks to be a highly competitive market

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This review explores the complex interplay between hyperkalemia and the use of guideline-directed medical therapies (GDMT), such as reninangiotensinaldosterone system inhibitors (RAASi) and steroidal mineralocorticoid receptor antagonists (sMRAs), including spironolactone and eplerenone, which are currently recommended in guidelines for improving outcomes in heart failure with reduced ejection fraction (HFrEF)