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This study, together with a companion manuscript, shows that in mice, weight loss as a result of GIP receptor antagonism requires and potentiates functional GLP-1 receptor signalling in the brain, explaining how both GIP receptor agonists and antagonists trigger weight loss through different mechanisms.

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In addition, activating GLP-1R protected mitochondria against the TGF-1+IL-1-induced increase in oxidative phosphorylation in fibroblasts