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Nutrient-induced metabolic stress, adaptation, detoxification, and toxicity in the pancreatic -cell
It signals satiety to the brain through pathways in the hypothalamus
Evidence base : Semaglutide has been studied in large, randomized controlled trials involving tens of thousands of patients, with well-established safety and efficacy profiles
[DOI] [PubMed] [Google Scholar] 52.American Diabetes Association Professional Practice Committee
JCI Insight 5 , e133429 (2020)
[DOI] [PMC free article] [PubMed] [Google Scholar] 716.Alhadeff A.L., Grill H.J
