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Without a thoughtful nutrition and lifestyle strategy, GLP-1 users risk losing muscle and bone mass as well

Indications for sitagliptin include use in type 2 diabetes as monotherapy or in combination with metformin or thiazolidinediones

Nat Rev Gastroenterol Hepatol 21 , 664666 (2024)

We dont yet know how long GLP-1 agents must be taken, or at what age, to achieve durable prevention

In a Phase 2 clinical trial involving adults with obesity, participants receiving the highest dose achieved an average weight reduction approaching 24% at 48 weeks , among the largest weight losses reported with a medication