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Eur Rev Med Pharm Sci

Darwesh AM, El-Azab MF, Abo-Gresha NM, El-Sayed NM, Moustafa YM

People with diabetes who were over the age of 55 and taking metformin a prescription drug most commonly used to treat type 2 diabetes were 37% less likely to develop intermediate age-related macular degeneration (AMD) over five years compared to those not taking it

Regarding fibrosis, while direct anti-fibrotic mechanisms are less established, preclinical studies indicate that GLP-1 RAs could suppress fibrogenic cell activation and reduce expression of pro-fibrotic genes encoding extracellular matrix proteins, potentially facilitating fibrosis regression in conjunction with improvements in steatosis and inflammation [29-32]