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Your provider monitors safety throughout the program

If the stopper becomes visibly damaged or starts to core (releasing rubber fragments), stop using the vial regardless of how many days remain

In clinical practice, weight losses of 5% and 10% are commonly used thresholds for clinical significance. PCOS guidelines state that a weight reduction of 5% can significantly improve insulin sensitivity and hyperandrogenic load, while 10% weight loss is strongly linked to restored ovulation and improved pregnancy rates (39, 78)

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This is where the answer gets more nuanced

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