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Conversely, GLP-1 RAs demonstrated no significant benefits in improving neurocognition or psychosocial functioning in schizophrenia, cocaine addiction, or dementia

Precautions and Warnings Semaglutide is not recommended for use in certain populations

Some individuals can wean off faster than others, especially if they are on a lower dose and have not been on the GLP-1 receptor agonist for long, in comparison to patients on the maximum dose and have been on the drug long-term

Christie, S

Recent early phase clinical trials have demonstrated a higher percentage of MASH resolution in patients who were treated with GLP-1 agonists compared to placebo, although they have not yet shown a statistically significant improvement in fibrosis stage 9

However, TALLYHO, but not lean, mice had significantly higher airway thymic stromal lymphopoietin (TSLP) in BALF following allergen challenge compared to saline challenge