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Participants were assigned to weekly injections of retatrutide at varying dosesranging from 1 mg up to 12 mgor to matching placebo, with both groups receiving lifestyle counseling throughout the study period

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During insulin resistance (IR), glucose metabolism converges in mitochondria via insulin signalling causing diabetes progression [57]

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Given the observed data and sampling variability, it provides a range of values within which the true effect size is likely to fall