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Description
Results from a phase 1 trial have supported further clinical evaluation with a dose-dependent WL up to 14.5% with AMG133 compared to 1.5% with placebo by day 85 [59]
In 2009, the first compound demonstrating anti-obesity effects was reported, a dual agonist targeting both the GLP-1 receptor and the glucagon receptor [24]

Randomized, double-blind, phase 3 trial of triple therapy with dapagliflozin add-on to saxagliptin plus metformin in type 2 diabetes
Erratum in: Lancet

GLP-1 signaling can get lost in the noise of inflammation, because L-cells are both hormone and immune-releasing cells

The risk of hypoglycemia is increased if the drug is used in combination with sulfonylureas or insulin
