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Many patients maintain weight loss long-term with continued medical guidance, balanced eating, and regular physical activity

These findings highlight the importance of maintaining continuous GLP-1 treatment to sustain cardiovascular benefits and indicate that strategies to reduce treatment discontinuity should be developed to maximize the cardioprotective effects of GLP-1s

The effects of these peptides in the hypothalamus are mediated through the activation of PKA, PKC and PI3K, as well as the phosphatase PP2

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Findings from human trials have demonstrated only a modest effect of GLP-1 analog administration on heart rate

This raises the question of what is the physiological role of GLP1 receptors in the circumventricular organs