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The net effect on any individual patient depends on the balance between potential adverse effects and the benefits of weight reduction

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Substance abuse Substance abuse, including alcohol and tobacco use, is prevalent among individuals with depression and significantly contributes to the development of T2DM and related complications [42, 43]

Where available, adverse effect information from cited human studies is also summarized in Table SIII and briefly noted in the corresponding cancer-specific subsections

Stress-management techniques like journaling or deep breathing also help regulate appetite-related hormones