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In extensive studies involving large groups of individuals, the utilization of incretinbased therapy did not demonstrate a higher likelihood of hospitalization due to severe pancreatitis [163] or pancreatic cancer [164]

A study conducted at the University Medical Centre Ljubljana in Slovenia followed 25 women with PCOS who were treated with semaglutide (1.0 mg weekly) and metformin for 16 weeks

A recent publication from JAMA on the analysis of people who have been taking GLP-1 agonists from 2006 to 2020 shows that people who are taking GLP-1 agonists have a nine-fold higher risk of developing acute pancreatitis compared with the older drug for weight loss, bupropion, and four times more frequent intestinal obstruction and three times more frequent gastroparesis

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Because SUMO expression is increased in mouse islets exposed to high glucose (Rajan et al., 2012), its interaction with GLP-1R may in part contribute to the reduced efficacy of incretin therapies in some T2DM patients with poorly controlled hyperglycemia (Fritsche et al., 2000

[DOI] [PubMed] [Google Scholar] 548.Tschen S.I., Dhawan S., Gurlo T., Bhushan A