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Estudios experimentales han determinado que estos frmacos disminuyen la expresin de la metaloproteinasas 2, que se encargan del remodelamiento de la matriz extracelular, reduce la infiltracin monocitaria en el endotelio vascular, la expresin de molculas de adhesin celular y promueve el cambio fenotpico de los macrfagos M1 (pro-inflamatorios) al M2 (anti-inflamatorios)

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This is the first weight loss treatment to target three key hormone pathways and potentially lead to greater weight loss, whilst providing additional benefits on fat metabolism and reducing the risk of fatty liver disease