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Metagenomic and metabolomic analyses reveal that the combined intervention is more effective at reshaping the gut microbial community than metformin alone

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Too slow If youre losing less than 0.5% body weight per week after the first month, consider: Whether youve reached an adequate dose Reviewing your dietary habits Checking for medication interactions Discussing with your prescriber about what dose is right for you Remember that NICE requires at least 5% weight loss by 6 months to continue treatment 6

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