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Risk of bias was assessed using an adapted Quality Assessment Tool for In Vitro Studies (QUIN) tool

The key distinction: MOTS-c focuses on improving function at the cellular level by supporting mitochondrial health

we conducted this emulated target trial to evaluate the risk of developing incident PsA in T2DM patients treated with SGLT2i, GLP-1 RA, and DPP-4i.

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Mechanistic hypotheses include reduced leptin-driven T-helper (Th)1/Th17 activity, improved adipokine balance, and modulation of gut-thyroid axis pathways

Certain genetic variants, carried by around 10 percent of the population, could be making type 2 diabetes GLP-1 treatments (such as Ozempic and Wegovy) less effective, according to new research.