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Coauthors of the study include Kamika Reynolds and Kimberly OMalley of the Institute for Health and Jason Roy of the Rutgers School of Public Health

Compared with non-GLP-1RA anti-diabetes medications, semaglutide was associated with a significantly lower risk of incident CUD, though the association attenuated over time

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First author Dr Mette Kruse Klausen added: "This is a patient group with a high disease burden and a substantial risk of both physical and mental complications

Centrally, GLP-1 receptor agonists act on hypothalamic appetite centers to increase satiety and reduce hunger signals

Published in the prestigious NEJM (New England Journal of Medicine) in 2015, the Satiety and Clinical Adiposity Liraglutide Evidence in Nondiabetic and Diabetic Individuals (SCALE) Obesity and Prediabetes Study, or SCALE study, was a multicenter randomised controlled trial which ran from June 1, 2011, through March 18, 2013, at 191 sites in 27 countries in Europe, North America, South America, Asia, Africa, and Australia