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Phasic burst firing of midbrain dopamine neurons and subsequent phasic release of dopamine in the nucleus accumbens are key neurophysiological mechanisms that implicate mesolimbic dopamine signaling as critical for goal-directed behaviors including drug reinforcement [3641]

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Reaching that target matters enormously because it significantly reduces the risk of diabetes-related complications including neuropathy, retinopathy, and kidney disease

doi: 10.1111/obr.13326 [DOI] [PMC free article] [PubMed] [Google Scholar] 23.Wharton S, Liu A, Pakseresht A, et al

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GLP-1 Receptor Agonists Mechanism of Action GLP-1 receptor agonists, such as semaglutide, liraglutide, and tirzepatide, mimic the natural GLP-1 hormone