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While lifestyle modifications such as dietary changes, increased physical activity, and behavioral therapy remain the foundation of treatment, their long-term effectiveness is often limited, especially in cases of severe obesity

This reflects adaptive remodeling , not disease

In patients with T2DM and NAFLD, dulaglutide has been shown to significantly reduce levels of liver injury biomarkers compared to placebo at 6 months of treatment [79]

As researchers explore these peptides, a natural question arises: how do they compare

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Neurons co-expressing orexigenic neuropeptide Y (NYP) and agouti-related peptide (AgRP) in the ARH activate melanocortin hormone- and orexin-expressing neurons in the lateral thalamus, leading to increase food intake