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Prepare the Injection Site Cleanse the selected injection site with an alcohol swab and allow it to dry completely before injecting the medication

The TRIUMPH-4 Phase 3 readout in April 2026 extended that to 28.7% at 68 weeks in a population with knee osteoarthritis - a patient group in whom weight loss produces disproportionate benefit on a secondary outcome (pain) the trial measured and reported as a 75.8% reduction on the WOMAC pain index

Glucagon receptor agonists carry a theoretical (though unconfirmed in humans) thyroid C-cell concern

Weight reduction is likely mediated by delayed gastric emptying, enhanced satiety, and reduced caloric intake 16

But studying cannabis isn't easy, and much of the information is on younger people, who tend to have the highest rates of cannabis use

Makin says