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Physical exercise: +30% of GLP-1 Types of effective exercises: Moderate (optimal) cardio: Brisk walking: 30-45 min, 5 times/week Cycling: 30-60 min, 3-4 times/week Swimming: 30 min, 3 times/week Increases GLP-1 during and 2-3 hours after exercise Strength training/resistance: 2-3 sessions/week = Improves insulin sensitivity + long-term GLP-1 HIIT (High Intensity Interval Training): 15-20 min, 2 times/week = Acute GLP-1 boost + 24h metabolism Ideal timing: 30 minutes after meals (improves blood sugar management + GLP-1) 2

doi: 10.1111/dom.13494

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Liraglutide and obesity: a review of the data so Far

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These considerations are especially important, as CMS has opted not to require coverage for obesity treatments in Medicare for 2026, leaving commercial payers to independently navigate the issue