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Cosmos Study October 14, 2025 Dual-Team Study Team A:Kersten Bartelt, RNEric Barkley Team B:Joel Jones, PharmDJoe Deckert, PhD Key Findings Among non-diabetic patients without chronic kidney disease (CKD), there was a minimal increase of 0.01 mg/dL to 0.02 mg/dL in serum creatinine in the months following initiation of semaglutide, liraglutide, or tirzepatide

First, we excluded case and non-case reports with gastrointestinal events (all PTs belonged to gastrointestinal disorders in the system organ class) in the dataset

Further studies focusing on the mechanism of action and active ingredients of natural compounds need to be performed using modern scientific and technological means to provide evidence-based support for their rational clinical application

Sleep and Stress Good sleep and lower stress help weight loss and overall health

While some studies show that it can be just as effective when treating weight loss and BMI, others show that semaglutide can produce as much as 9.4% more weight loss over 68 weeks
