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A brief note on perimenopause: weight change often shows up alongside other shifts like irregular periods, sleep disruption, and mood changes

17 Similarly, in a meta-analysis of 14 RCTs in T2DM patients conducted by Liu et al, tirzepatide was shown to provide superior HbA1c reduction and improved metabolic outcomes compared to placebo, insulin, and all other GLP-1 RAs at all doses examined

If needle phobia is a barrier to starting treatment, oral options remove that obstacle

This has led medical societies to issue guidance on managing these medications before elective procedures

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Appleton highlighted several important remaining gaps in the understanding of GLP-1-based therapies for OA