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In Proceedings of the Clinical Trials on Alzheimers Disease (CTAD) (Oral Presentation, San Diego, CA, USA, 2025)

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Semaglutide, the active ingredient in Wegovy and other GLP-1 medications, works by slowing stomach emptying and signaling fullness to your brain

Dosing adjustments and special considerations Holding or reducing dose When to hold at current dose: Moderate-to-severe GI symptoms Symptoms that haven't resolved after 3-4 weeks Any concerning side effects When to reduce dose: Symptoms intolerable at current level Significant weight loss plateau doesn't require maximum dose Maintenance phase after reaching goals How to hold: Stay at current dose for an additional 2-4 weeks Then attempt escalation again If symptoms recur, may need to maintain at lower dose Missed dose protocol If you miss a dose: Take it as soon as you remember if within 4-5 days If more than 5 days, skip and resume normal schedule Never double dose to make up for missed injection If you frequently miss doses: Set weekly reminders Choose a consistent day (many choose Sunday) Consider adjusting day if schedule conflicts Population considerations For those with kidney impairment: Limited data available Slower titration may be warranted More frequent monitoring recommended Discuss with provider before starting For those with liver impairment: Retatrutide is hepatically metabolized Caution in moderate-to-severe liver disease May need dose adjustments Requires provider guidance For women: Similar dosing to men in trials May have stronger appetite suppression effects Some may need slower titration Contraception recommended during treatment For older adults: May need slower titration Increased monitoring for dehydration Start at lowest dose More frequent check-ins Comparing retatrutide dosing to other medications Retatrutide vs

These areas either lack adequate subcutaneous tissue or contain important blood vessels and nerves that should not be disturbed