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This interaction happens because of a specific group of compounds in grapefruit called furanocoumarins

Liu, C., Zhang, M., Hu, M

Reuse the dose tables below it to convert your prescribed dose into volume and insulin syringe units

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11 This adverse effect may be related to GLP-1 R activation in the CNS, which can influence cerebrovascular tone and regional blood flow, potentially resulting in cerebral vasodilatation and headaches due to mechanical strain on pain-sensitive structures

Accordingly, it has several metabolic effects consistent with the actions of GLP-1 and glucagon (stimulation of insulin secretion, reduced appetite, increased energy expenditure), although whether these are important physiologically is uncertain (55)