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The medication works through dual incretin receptor agonism affecting glucose metabolism, insulin secretion, and appetite regulationnone of which involve direct renal tubular effects on sodium and water reabsorption that characterize true diuretic agents

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Teichholz, L

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The largest for any selective GLP-1R agonist

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The inclusion of semaglutide based products in Medicare price negotiations represents a step toward addressing excessive pricing, but falls short of resolving the fundamental systemic issues of the patent system that companies exploit at the expense of patients

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