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Keywords: type 2 diabetes, obesity, glucagon-like peptide-1 receptor agonists, gastrointestinal adverse events, guidelines 1

GLP-1RA are indicated for diabetes and obesity, which in turn are concomitant risk factors for depression and SIS

Impaired insulin sensitivity promotes adipose tissue hydrolysis, increasing circulating FFAs, which accumulate in hepatocytes, leading to steatosis (the first hit) [41]

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2026 Trends: While exact 2026 national hospital figures are still being tracked, regional research from the University of New Mexico shows that up to 44% of reported GLP-1 exposure cases in 2026 are severe enough to require an immediate emergency room visit.

This region typically has adequate subcutaneous tissue in most adults, though individuals with very low body fat may find this site less suitable