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In a retrospective cohort study of patients with type 2 diabetes, coadministration with serotonergic antidepressants (eg, citalopram/escitalopram) was associated with attenuation of the weight loss effects of GLP-1 agonists

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It has also been suggested that brain penetrance differs between different GLP-1 analogs, with nonacylated and non-PEGylated analogs like exendin-4 or lixisenatide showing significant rates of brain influx, while liraglutide or semaglutide do not have reliable BBB crossing (143), at least in male mice

To view or add a comment, sign in GLP-1 Drugs: My Take as a Pharmacist Every week, I see articles warning about the dangers of GLP-1 drugs like Ozempic, Wegovy, and Mounjaro

2022;13:e46

JPB, SS, RGM, BC and HS reviewed and substantively revised the manuscript