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Terami et al revealed that diabetes-induced disruption of the BBB allowed SGLT-2is to pass through in a dose-dependent manner

The brain regions and neural circuits involved in the central actions of GLP1 are highly plastic or malleable (Lieu et al., 2020)

Any person on a GLP-1 RA who has an acute change in their vision should be assessed rapidly

Normal dip: Glucose rises, insulin helps clear it, and levels return smoothly toward baseline

Basic science and clinical research evidence indicates that GLP-1RAs produce direct immunomodulatory actions that function separately from weight loss

Why the JPML Created a Separate MDL for NAION Claims One of the most important aspects of this decision is what the JPML did not do: rather than folding NAION claims into an already-existing GLP-1 products liability MDL, the panel chose to establish an entirely separate MDL dedicated specifically to NAION claims