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When renal ischemia-reperfusion injury occurs, the dynamic balance between the two axes is disrupted

Nuclear Magnetic Resonance (NMR) and other fractionation methods (e.g., TREF, CRYSTAF, SSA) have been successfully used to differentiate the content of PP into its fractions, but these methods are expensive (time and investment) and require a high level of expertise

The concept presented here paves the way for the interlinked network between dynamic supramolecular assemblies and cellular regulatory behaviors

10.1371/journal.ppat.1004237 165 MadabhushiR.PanL.TsaiL.-H

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However, despite the prevalence of the natural (R)-SFN enantiomer, many studies investigating SFNs biological activities have been conducted using the racemic form, which contains both (R)-SFN and (S)-SFN in equal proportions [132]
