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Immunohistochemical staining for GLP1-R, insulin, and proinsulin immunoreactivity Membranous immunoreactivity of GLP- 1R and cytoplasmic immunoreactivity of insulin and proinsulin were evaluated semi-quantitatively using the immunoreactive score (IRS) [17]

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Metabolic effects of two years of exenatide treatment on diabetes, obesity, and hepatic biomarkers in patients with type 2 diabetes: an interim analysis of data from the open-label, uncontrolled extension of three double-blind, placebo-controlled trials