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Safety, outcomes, and T-cell characteristics in patients with relapsed or refractory MDS or CMML treated with atezolizumab in combination with guadecitabine

Given the advancements in genome-editing technology obtained with the CRISPR/Cas9 system, human Fabry disease can be readily modeled in a pathologically and genetically relevant manner

doi: 10.1016/j.cvfa.2008.10.003 [DOI] [PMC free article] [PubMed] [Google Scholar] 52

By simultaneously increasing the rate of fat breakdown while decreasing the rate of new fat formation, AOD9604 creates a net catabolic effect on adipose tissue stores
417,418,419 Various such agents, including those dual-targeting HDACs and kinases, receptors, DNA, transcriptional factors, and apoptosis-related proteins, are under preclinical investigation

Ferro C, Florindo HF, Santos HA
