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GHK plasma levels naturally decline from approximately 200 ng/mL at age 20 to under 80 ng/mL by age 60, and microinfusion replenishes that depletion directly at the dermal layer

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This finding suggests that PTEN mutations are an additional subgroup of ser/gly high GBMs, along with PSPH amplification and PSPH V116I mutation, which could benefit from (neo)adjuvant sertraline treatment

196 showed that cystine levels are lower in tumour interstitial fluid in murine pancreatic adenocarcinomas (PDACs) than in plasma, which may indicate that cancer cells actively uptake cysteine
