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Walaa Abuzahra for coordinating the data collection process

Because IGF-I exerts anti-inflammatory actions and is important for peripheral glucose uptake, metabolic disturbances in these patients can, in part, be explained by the low IGF-I levels (83)

It is calculated as: QUICKI = 1/(log[Insulin U/mL] + log[Glucosemg/dL]) Patients with QUICKI index below 0.357 tend to have a higher risk of IR or frequently present with manifestations typical of metabolic syndrome

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(2013) Structural changes in hippocampal subfields in major depressive disorder: a high-field magnetic resonance imaging study

The association to 5MTHF of (methyl)B12 and of other micronutrients in support to the pathway is likely to increase the efficacy, to enlarge the rate of responding patients and to avoid safety issues including the folate trap syndrome