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Vyvanses manufacturer sought FDA approval in depression augmentation, where it showed early promise in Phase II trials (Trivedi MH et al, J Clin Psychiatry 2013;74(8):802809

If it progresses, however, more blood spills backwards through the leaky mitral valve, and the ventricle has to pump harder to meet the bodys demands for oxygenated blood

Its unique mechanism of action aims to provide greater efficacy compared to single-receptor agonists

References Sharma, S., Sankhyan, N., Gulati, S

doi: 10.1007/s12603-022-1853-1 64

Schwartz, MW Obesity is associated with hypothalamic injury in rodents and humans J Clin Invest 122 1: 153-62