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2.1.2 Mechanisms linking decreased NAD + levels to MetS Decreased NAD + levels are associated with obesity, with studies demonstrating reduced NAD + levels in obese individuals

& van Schooten, W

Individual factors such as metabolic rate, body weight, and age may theoretically influence how B12 is distributed and utilised, though evidence for their impact on injection intervals is limited

Frontiers in Cardiovascular Medicine, 6