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Cell 83 , 942960.e949 (2023)

This chapter aims to summarize the current experimental and clinical evidence about the major oxidant and antioxidant changes occurring in hypertension and heart failure, and to provide a critical overview of the relevance of oxidative stress in the pathophysiology of these prevalent diseases

Rights and permissions About this article Cite this article de Assis, L.V.M., Moraes, M.N

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The proposed mechanism involves controlling glutamate release in the synaptic cleft, modulating NMDA receptor stimulation, affecting excitatory amino acid transporter (EAAT)-mediated reuptake, and maintaining the glutamate/glutamine cycle within astrocytes
