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The deprotonation event may involve the active site histidine residues, which would then allow for direct metal insertion

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The reducing catechol groups of PDA have further been explored to form well-dispersed AgNPs on different substrates for controlling biofouling and as antimicrobial reverse osmosis membranes, which, in turn, expose the potential of PDA to modify surface chemistries and morphological features of the membranes (Tang et al., 2015