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Combine it with a sensible nutrition plan

Clozapine-induced reduction of l-carnitine reabsorption via inhibition/down-regulation of renal carnitine/organic cation transporter 2 contributes to liver lipid metabolic disorder in mice

further suggest that the dual impairment of the intestinal and blood-brain barriers establishes a critical gut-brain axis pathway that jointly promotes disease progression (9)

Additionally, the role of the microbiota has been investigated, since L-carnitine can be transformed into TMAO , a metabolite that has been associated with cardiovascular risk in some observational studies

Second, a moderate dose of L-carnitine and a relatively short intervention period (7 days) were employed, potentially influencing the observed outcomes