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Also, administration of melatonin exerts hepatoprotective effects in a rat model of CPB( cardiopulmonary bypass model) and SIRS(systemic inflammatory response syndrome) by reducing the ROS generation which is well demonstrated in biochemical and histo-pathological experiments [57,58]

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220,221,222 Thus, the blockade of enzymes that contribute to the production of H 2 S constitutes an attractive anti-cancer strategy

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