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GLP-1 is an incretin hormone that stimulates insulin secretion in a glucose-dependent manner, reducing hypoglycaemia risk The hormone slows gastric emptying and suppresses appetite through receptors in the pancreas, brain, and gastrointestinal tract GLP-1 receptor agonists (semaglutide, liraglutide, dulaglutide) are MHRA-approved for type 2 diabetes and weight management Common side effects include nausea, vomiting, and diarrhoea due to delayed gastric emptying and altered gut motility Patients should seek urgent medical attention for severe abdominal pain with persistent vomiting, as this may indicate pancreatitis GLP-1 medications do not directly impair digestive enzyme production, and routine enzyme supplementation is not clinically indicated Table of Contents What Does GLP-1 Stand For

We hope Tirzepatide (a dual GLP-1/GIP RA) will soon get approved in this crucial indication as it has been approved in OSA

Electronic Medicines Compendium (EMC) , 3 July 2024, Accessed 15 July 2025

The initial dose is one tablet daily, which should be increased over a four-week period to the recommended dose of two tablets twice daily (32 mg naltrexone and 360 mg bupropion per day)

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With smart planning, you can build a strong foundation for successful and lasting weight loss