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In vivo administration of DSF/Cu in murine tumor models significantly increased the abundance of tumor-infiltrating lymphocytes and potentiated anti-tumor response to PD-1 checkpoint blockade

In contrast to the replenishment of GSH precursors, System Xc- activators primarily enhance the expression of SLC7A11 to promote the uptake of cystine, which is both a specific substrate and a direct activator of the system (137)

Lee KK, Imaizumi N, Chamberland SR, Alder NN, Boelsterli UA

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