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While tirzepatide is not primarily eliminated through the kidneys, the gastrointestinal effects of the medication, including potential nausea, vomiting, and diarrhea, could lead to dehydration and electrolyte imbalances that may be particularly problematic in patients with compromised kidney function

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Doctors or clinics may offer compounded semaglutide with B12 to provide both benefits at once

Regulation of OCTN2 transporter (SLC22A5) by peroxisome proliferator activated receptor alpha