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S-Adenosyl-L-Methionine (SAM), metabolite involved in the transsulfuration pathway

Plan phases : Break long goals into manageable chunks Schedule transitions : Plan what comes after Build in flexibility : Adjust based on results Track and reassess : Monthly check-ins on progress Read our getting started guide for fundamentals

Functionally, PDK4 stabilizes KRAS localization at the plasma membrane, activating the MAPK and NRF2 pathways to sustain redox homeostasis and enhance DNA damage repair, thereby reinforcing cisplatin resistance [154, 155]

10.3390/ijms24010470 Int

This leads to a decrease in overall antioxidant capacity [120, 121]
