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In an interesting and similar study by Hu et al., intravenous administration of Congo red/rutin magnetic nanoparticles (MNPs) resulted in rescue of memory deficits and amelioration of neurologic changes in the brains of APPswe/PS1dE9 transgenic mice [160]

In probing why, they soon discovered one team member originally bought the wrong type of special laboratory mice

This was clearly demonstrated by a study in which primary cortical neurons treated with subtoxic levels of the GSH-depleting agent, buthionine sulfoximine (BSO), underwent apoptosis in the presence of trace amounts of extracellular copper [17]

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