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Carlsson J, Kierstan MPJ, Brocklehurst K

74,94 Together, these observations provide strong evidence that peroxynitrite formation in mitochondria is a critical cytotoxic mediator in the pathophysiology of APAP hepatotoxicity

In the nucleus, GSH is a key regulator of cellular division (see review by Pallard et al., 2008 in this issue.) While lungs are clearly adversely affected by lowered intracellular and extracellular GSH, the majority of studies on the pathologies involving GSH transport and metabolism have been done in liver

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387,390 Alpers-Huttenlocher syndrome is likely the most common POLG -related disorder
