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Additionally, key molecular alterations, including EGFR amplification, IDH mutations, O 6 -methylguanine-DNA methyltransferase (MGMT) modifications, histone epigenetic changes and signaling pathway dysregulation, are being examined for their contributions to the aggressive behavior and treatment challenges of GBM

[DOI] [PubMed] [Google Scholar] 95.Zhao B, Ni C, Gao R, Wang Y, Yang L, Wei J, et al