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As HbS polymers grow, they herniate through the membrane skeleton and project from the cell ensheathed only by the lipid bilayer
"S-Adenosyl Methionine and Transmethylation Pathways in Neuropsychiatric Diseases Throughout Life"

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Considering p53s role in governing the expression of multiple genes associated with the biogenesis of Fe-S clusters, it is plausible to suggest that this mechanism may represent another pathway by which p53 regulates cuproptosis
Ferritinophagy: research advance and clinical significance in cancers
Both the amount of resin used and the column size can be scaled up or down depending on the amount of protein to be purified
