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Vaginal smear was daily obtained as described previously 42 and only those showing at least two consecutive normal vaginal estrus cycles (45 days) were used in the experiments

It is important to understand how the cells discriminate between the signals and activate signal-specific PLC/PLCs whether the PLC isoforms work independently or work in a coordinated manner

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We showed for the first time the presence of a series of sphingoid bases in C

A 2007 double-blind, multicenter trial (n=102) showed ALC 1,500 mg/day significantly improved tender point count, total myalgic score, depression, and musculoskeletal pain compared to placebo.[9] A 2015 RCT found ALC 1,500 mg/day comparable to duloxetine 60 mg/day for pain and depression.[8] Most notably, a 2023 RCT demonstrated that adding PEA 1,200 mg/day + ALC 2,000 mg/day to ongoing duloxetine + pregabalin therapy produced significantly greater improvements in Widespread Pain Index, FIQR, and FASmod scores.[7] Role in Treatment: ALC can be used as monotherapy or adjunctive therapy in fibromyalgia