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Laboratory analytical applications

This relationship has been demonstrated in experimental animal models and observational human research [73, 74]

Gastrointestinal infections and the development of irritable bowel syndrome

For example, the known protein phosphatase protein tyrosine phosphatase B (PtpB) from Mycobacterium tuberculosis dephosphorylates phosphatidylinositol-4-phosphate and phosphatidylinositol-(4,5)-bisphosphate in host cell membranes, which disrupts the membrane localization of cleaved gasdermin D (GSDMD), thereby inhibiting cytokine release and pyroptosis in macrophages

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