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10.1016/S0092-8674(00)80595-4 Cell 10 ButtgereitF.BrandM

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5 Therapeutic implications and challenges The delineation of the ferroptosis-immune-metabolic axis in COPD unveils a new frontier for therapeutic intervention

Deletion of metJ , the transcriptional repressor for L-methionine and SAM biosynthesis, in this strain could enhance SAM supply to EGT biosynthesis by elevating transcriptional level of metK that encodes methionine adenosyltransferase

This leads to augmented thalamocortical GABAergic inhibition by enhancing the inhibitory projection from the globus pallidus/substantia nigra pars reticulata
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